Thymic Involution and Immune Aging: Can Peptides Help?
The thymus shrinks with age and naive T-cell output falls. What thymosin alpha-1 and the TRIIM study show, and what would count as real proof.
Supplements
Immune Modulation
2 articles on Immune Modulation by Julian Douwes, M.D., from the Supplements library.
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Thymosin Alpha-1 for Long COVID: Immune Restoration When the Immune System Stays Broken
How thymosin alpha-1 addresses the core immune dysfunction of long COVID — T-cell exhaustion, NK cell deficiency, and chronic viral persistence — with dosing protocols.
03
Ozone Therapy for Autoimmune Disease: Evidence, Patient Selection, and Integration
How medical ozone modulates immune dysregulation in rheumatoid arthritis, lupus, multiple sclerosis, and Hashimoto's — with protocols, contraindications, and outcome data.
04
Black Seed Oil (Nigella Sativa): Thymoquinone's Role in Immune Balance and Inflammation
A physician's evidence-based guide to black seed oil and thymoquinone—dosing, mechanisms, clinical uses in MCAS, autoimmunity, and metabolic health, plus who should avoid it.
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Low-Dose Naltrexone for Lupus (SLE): Evidence, Dosing, and Clinical Considerations
LDN modulates TLR4 signaling and reduces type-I interferon activity in SLE. Review the clinical evidence, dosing titration, flare monitoring, and drug interactions.
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Low Dose Naltrexone for Psoriatic Arthritis: Evidence, Protocols, and Clinical Insights
How LDN modulates opioid growth factor receptors and neuroinflammation to reduce psoriatic arthritis joint pain and skin flares — dosing, evidence, and who benefits most.
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Low Dose Naltrexone for Hashimoto's Thyroiditis: Clinical Evidence and Protocol
How LDN modulates thyroid autoimmunity, reduces TPO antibodies, and improves symptoms in Hashimoto's. Dosing protocols, mechanisms, and patient selection criteria.
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Low-Dose Naltrexone for Multiple Sclerosis: Evidence, Dosing, and Clinical Considerations
A clinical guide to low-dose naltrexone (LDN) in multiple sclerosis: mechanisms, clinical trial data, dosing protocols, patient selection, and integration with DMTs.
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Low Dose Naltrexone for Crohn's Disease and Ulcerative Colitis
How LDN modulates gut immunity, reduces inflammation, and offers a low-risk adjunct in IBD — dosing, evidence hierarchy, patient selection, and monitoring.
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Andrographis Paniculata: Evidence, Dosing, and Clinical Use in Lyme Disease and Immune Support
A clinician's guide to andrographis paniculata—active mechanisms, RCT evidence for respiratory infections, Lyme disease adjunct protocols, dosing, and safety considerations.
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Ultraviolet Blood Irradiation (UVBI): A Physician's Clinical Protocol Guide
Dr. Julian Douwes explains UVBI therapy — mechanisms, clinical indications, treatment protocol, contraindications, and how it compares to IV laser and ozone.
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Probiotics for Allergic Disease: From Adjunct Supplement to Immune-Modifying Strategy
How specific probiotic strains shift Th2-dominant immune responses in allergic rhinitis, eczema, food allergy, and asthma — a clinical guide to strain selection and protocol design.
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Low-Dose Naltrexone for Long COVID and Post-Viral Fatigue: Clinical Evidence and Protocol
LDN reduces neuroinflammation and immune dysregulation driving long COVID fatigue. Clinical evidence, dosing protocol, and how LDN fits a multimodal recovery plan.
14
Peptides for Autoimmune Disease: A Physician's Evidence-Based Guide
Discover how immunomodulatory peptides like Thymosin Alpha-1, BPC-157, and LL-37 can help regulate immune dysfunction in autoimmune conditions. Clinical protocols and evidence.
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Bovine Colostrum: Clinical Evidence for Immune Modulation and Gut Healing
A physician's review of bovine colostrum supplements — immune IgA, growth factors, leaky gut, and how to use it clinically. Evidence-graded and protocol-ready.
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Peptide Therapy Benefits: A Physician's Evidence-Based Overview
Dr. Douwes reviews the clinically relevant benefits of peptide therapy — from tissue repair and immune modulation to longevity and brain health. What evidence supports each claim.
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Low-Dose Naltrexone (LDN): Clinical Evidence for Chronic Illness and Autoimmunity
Low-dose naltrexone modulates immune function and reduces neuroinflammation. Evidence-based overview of LDN dosing, mechanisms, and clinical applications.
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Ozone Therapy vs. IV Laser Therapy: A Physician's Clinical Comparison
Dr. Douwes compares ozone therapy and IV laser therapy—mechanisms, clinical indications, safety profiles, and when to combine both in integrative practice.
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Hyperthermia for Cancer: Evidence, Protocols, and Clinical Experience
Hyperthermia cancer treatment evidence from RCTs and 35 years of clinical use. How moderate and extreme WBH synergize with chemo and radiation therapy.
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Mistletoe Therapy (Iscador): Evidence in Integrative Oncology
Mistletoe extract (Iscador, Helixor) for cancer: mechanism, NK cell activation, quality of life evidence, injection protocols, and the German clinical tradition.
21
Immune Modulation: Enhancing or Calming Immunity
How physicians enhance weak immune responses and calm overactive ones. Evidence-based immune modulation explained by Dr. Julian Douwes.
